Panopto supports a vast array of video and audio files. The list below provides a list of some of the supported file types.
Video: .mp4, .m4a, .m4v, .3gp, .wmv, .wma, .mjpeg, .mpeg, .f4v, .f4a, .avi, etc.
Audio: .mp3, .wma, .wav, .pcm, .ac3, .flv, etc.
A more comprehensive list is found here.